The Need-to-Know on PdG
PdG needs to rise and remain elevated during the second half of your cycle for successful ovulation to occur — and to allow for a higher chance at pregnancy.
When You'll Test:
Begin by taking 1 Confirm test early in your cycle (please refer to kit instructions for specific details). This is called your baseline and it will be negative — but is still super important!
You’ll save your other 4 tests to use during the key implantation window. The implantation window takes place days 7 through 10 after peak fertility, as indicated by an LH test, fertility tracking device, or cervical mucus.
Please refer to kit instructions for specific details.
Proov Confirm measures a hormone marker released after ovulation, called PdG, that supports implantation. Sustained, elevated PdG levels during the implantation window — days 7-10 after peak fertility — indicate a successful ovulation.
Proov is the only FDA cleared test to confirm successful ovulation by tracking PdG during the implantation window. A clinical study* shows when PdG levels remain high during the implantation window, pregnancy rates increase over 75%.
If PdG tests remain positive (one line) during the implantation window, this is a successful ovulation. Successful ovulation can also be indicated by a high Ovulation Score if you choose to use the Proov Insight app. Negative PdG test results during the implantation window or a low Ovulation Score means you are unable to confirm successful ovulation. If your results indicate you are ovulating successfully but you still haven’t conceived, we recommend checking your partner’s sperm, ensuring you’re timing intercourse correctly, or consulting a doctor. If your results indicate you are not ovulating successfully, we recommend consulting your doctor for treatment or learning about ways to naturally support progesterone production.
Measuring PdG levels provides insight into successful ovulation, a piece of the fertility puzzle that you can’t get from BBT or blood tests alone. After circulating through the bloodstream, progesterone is released from the body as the urinary marker, Pregnanediol Glucuronide (PdG). Sustained, elevated PdG levels during the second half of your cycle — the “implantation window” — is an indication of successful ovulation, which increases your chances of successful implantation and pregnancy by as much as 75%. Low PdG levels during the second half of your cycle may indicate a problem with ovulation that could make it more difficult to get pregnant.
People who might have a problem with ovulation might benefit from testing for PdG. This includes:
*Amy Beckley, Joshua Klein, John Park, Aimee Eyvazzadeh, Gary Levy, Alexandra Koudele. The predictive value of urinary progesterone metabolite PdG testing in pregnancy outcomes. Obstetrics and Gynecology Research 5 (2022): 194-198.